Synaptically activated Ca2+ release from internal stores in CNS neurons

被引:44
作者
Ross, WN
Nakamura, T
Watanabe, S
Larkum, M
Lasser-Ross, N [1 ]
机构
[1] New York Med Coll, Dept Physiol, Valhalla, NY 10595 USA
[2] Univ Tokyo, Inst Med Sci, Div Mol Neurobiol, Tokyo, Japan
[3] Inst Physiol, CH-3012 Bern, Switzerland
关键词
dendrite; calcium; pyramidal neuron; IP3;
D O I
10.1007/s10571-005-3060-0
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
1. Synaptically activated postsynaptic [Ca2+](i) increases occur through three main pathways: Ca2+ entry through voltage-gated Ca2+ channels, Ca2+ entry through ligand-gated channels, and Ca2+ release from internal stores. The first two pathways have been studied intensively; release from stores has been the subject of more recent investigations. 2. C2+ release from stores in CNS neurons primarily occurs as a result of IP3 mobilized by activation of metabotropic glutamatergic and/or cholingergic receptors coupled to PLC. Ca2+ release is localized near spines in Purkinje cells and occurs as a wave in the primary apical dendrites of pyramidal cells in the hippocampus and cortex. The amplitude of the [Ca2+](i) increase can reach several micromolar, significantly larger than the increase due to backpropagating spikes. 3. The large amplitude, long duration, and unique location of the [Ca2+](i) increases due to Ca2+ release from stores suggests that these increases can affect specific downstream signaling mechanisms in neurons.
引用
收藏
页码:283 / 295
页数:13
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