Hydrophobic polycationic coatings inactivate wild-type and zanamivir- and/or oseltamivir-resistant human and avian influenza viruses

被引：51

作者：

Haldar, Jayanta ^{[1
]}

Chen, Jianzhu ^{[2
,3
]}

Tumpey, Terrence M. ^{[4
]}

Gubareva, Larisa V. ^{[4
]}

Klibanov, Alexander M. ^{[1
]}

机构：

[1] MIT, Dept Biol & Chem Engn, Cambridge, MA 02139 USA

[2] MIT, Ctr Canc Res, Cambridge, MA 02139 USA

[3] MIT, Dept Biol, Cambridge, MA 02139 USA

[4] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA

来源：

BIOTECHNOLOGY LETTERS | 2008年 / 30卷 / 03期

关键词：

antiviral; polyethylenimine; quaternary amines; Relenza; Tamiflu;

D O I：

10.1007/s10529-007-9565-5

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 0836 [生物工程]; 090102 [作物遗传育种]; 100705 [微生物与生化药学];

摘要：

Glass slides painted with the hydrophobic long-chained polycation N,N-dodecyl,methyl-polyethylenimine (N,N-dodecyl,methyl-PEI) are highly lethal to waterborne influenza A viruses, including not only wild-type human and avian strains but also their neuraminidase mutants resistant to currently used anti-influenza drugs.

引用

页码：475 / 479

页数：5

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