Early asymmetry of gene transcription in embryonic human left and right cerebral cortex

被引：269

作者：

Sun, T

Patoine, C

Abu-Khalil, A

Visvader, J

Sum, E

Cherry, TJ

Orkin, SH

Geschwind, DH

Walsh, CA

机构：

[1] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Howard Hughes Med Inst, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Neurol, Boston, MA 02115 USA

[3] Univ Calif Los Angeles, Dept Neurol, Program Neurogenet, Sch Med, Los Angeles, CA 90095 USA

[4] Walter & Eliza Hall Inst Med Res, Victorian Breast Canc Res Consortium Lab, Melbourne, Vic 3050, Australia

[5] Boston Childrens Hosp, Howard Hughes Med Inst, Div Hematol Oncol, Boston, MA 02115 USA

[6] Dana Farber Canc Inst, Dept Pediat, Boston, MA 02115 USA

来源：

SCIENCE | 2005年 / 308卷 / 5729期

关键词：

D O I：

10.1126/science.1110324

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The human left and right cerebral hemispheres are anatomically and functionally asymmetric. To test whether human cortical asymmetry has a molecular basis, we studied gene expression levels between the left and right embryonic hemispheres using serial analysis of gene expression (SAGE). We identified and verified 27 differentialty expressed genes, which suggests that human cortical asymmetry is accompanied by early, marked transcriptional asymmetries. LMO4 is consistently more highly expressed in the right perisylvian human cerebral cortex than in the left and is essential for cortical development in mice, suggesting that human left-right specialization reflects asymmetric cortical development at early stages.

引用

页码：1794 / 1798

页数：5

共 23 条

[1] Wnt genes define distinct boundaries in the developing human brain: Implications for human forebrain patterning [J].