The inflammasomes in health and disease: from genetics to molecular mechanisms of autoinflammation and beyond

被引：89

作者：

Conforti-Andreoni, Cristina ^{[1
]}

Ricciardi-Castagnoli, Paola ^{[1
]}

Mortellaro, Alessandra ^{[1
]}

机构：

[1] ASTAR, Singapore Immunol Network, Singapore 138648, Singapore

来源：

CELLULAR & MOLECULAR IMMUNOLOGY | 2011年 / 8卷 / 02期

关键词：

autoinflammatory diseases; polymorphisms; NLRs; NLRP3; MULTISYSTEM INFLAMMATORY DISEASE; PATTERN-RECOGNITION RECEPTORS; INNATE IMMUNE-RESPONSES; LOW-LEVEL MOSAICISM; KAPPA-B ACTIVATION; NOD-LIKE RECEPTORS; NALP3; INFLAMMASOME; NLRP3; T-CELLS; CASPASE-1; ACTIVATION;

D O I：

10.1038/cmi.2010.81

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Nucleotide-binding oligomerization domain (NOD)-containing protein-like receptors (NLRs) are a recently discovered class of innate immune receptors that play a crucial role in initiating the inflammatory response following pathogen recognition. Some NLRs form the framework for cytosolic platforms called inflammasomes, which orchestrate the early inflammatory process via IL-1 beta activation. Mutations and polymorphisms in NLR-coding genes or in genetic loci encoding inflammasome-related proteins correlate with a variety of autoinflammatory diseases. Moreover, the activity of certain inflammasomes is associated with susceptibility to infections as well as autoimmunity and tumorigenesis. In this review, we will discuss how identifying the genetic characteristics of inflammasomes is assisting our understanding of both autoinflammatory diseases as well as other immune system-driven disorders. Cellular & Molecular Immunology (2011) 8, 135-145; doi:10.1038/cmi.2010.81; published online 24 January 2011

引用

页码：135 / 145

页数：11

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