The I′ potential of the human auditory brainstem response to paired click stimuli

被引:7
作者
Davis-Gunter, MJ
Löwenheim, H
Gopal, KV
Moore, EJ
机构
[1] Northwestern Univ, Sch Med, Dept Mol Pharmacol & Biol Chem S215, Chicago, IL 60611 USA
[2] Michigan State Univ, Auditory Neurosci Lab, Dept Audiol & Speech Sci, E Lansing, MI 48824 USA
[3] HNI Klin Tuebingen, Hoerforschungszentrum, Tubingen, Germany
[4] Univ N Texas, Dept Speech & Hearing Sci, Denton, TX 76203 USA
来源
SCANDINAVIAN AUDIOLOGY | 2001年 / 30卷 / 01期
关键词
auditory brainstem responses; compound action potential; excitatory post-synaptic potential; generator potential; summating potential;
D O I
10.1080/010503901750069572
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
When stimulated with an appropriate stimulus, the hair cells of the organ of Corti depolarize, causing the release of a neurotransmitter substance, which excites afferent VIIIth nerve dendrites. It is reasonable to hypothesize that excitatory postsynaptic potentials (EPSPs) generated by the dendrites of the auditory nerve in turn initiate a compound action potential (CAP). The EPSP is thought to be the generator potential for the CAP, and may be recorded in auditory brainstem responses (ABRs) as the I ' potential. Determining the anatomical origin of I ' may enhance the sensitivity of the ABR technique in hair cell/dendrite/auditory nerve evaluations. Whether I ' is of sensory or of neural origin is equivocal, and therefore I ' is not well understood. To investigate this dilemma, ABRs were recorded from human subjects using standard and paired-click stimuli, and using subtraction methods to generate a derived ABR. Two early peaks, designated as I degrees and I ', occurred before wave I in the derived ABR. It was hypothesized that peaks I degrees and I ' represent the summating potential and the generator potential, generated by the cochlea and VIIIth nerve dendrites, respectively.
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页码:50 / 60
页数:11
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