A concise stereospecific synthesis of repinotan (BAYx3702)

被引：24

作者：

Gross, JL ^{[1
]}

机构：

[1] Wyeth Res, Princeton, NJ 08543 USA

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 47期

关键词：

D O I：

10.1016/j.tetlet.2003.09.130

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A concise synthesis of the 2-[aminomethyl]chroman derivative BAYx3702 (3), a potent 5-hydroxytryptamine (5-HT1A) antagonist is described. Utilization of a Mitsunobu reaction of phenol (11) with the non-racemic allylic alcohol (12) and consequent ring-closing metathesis furnishes the chroman-2-yl framework of 3 in optically active form. (C) 2003 Published by Elsevier Ltd.

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页码：8563 / 8565

页数：3

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