Neuromyelitis optica and multiple sclerosis: Seeing differences through optical coherence tomography

被引：192

作者：

Bennett, J. L. ^{[1
,2
]}

de Seze, J. ^{[3
]}

Lana-Peixoto, M. ^{[4
]}

Palace, J. ^{[5
]}

Waldman, A. ^{[6
]}

Schippling, S. ^{[7
]}

Tenembaum, S. ^{[8
]}

Banwell, B. ^{[6
]}

Greenberg, B. ^{[9
,10
]}

Levy, M. ^{[11
]}

Fujihara, K. ^{[12
]}

Chan, K. H. ^{[13
]}

Kim, H. J. ^{[14
]}

Asgari, N. ^{[15
,16
]}

Sato, D. K. ^{[17
]}

Saiz, A. ^{[18
,19
]}

Wuerfel, J. ^{[20
,21
]}

Zimmermann, H. ^{[20
]}

Green, A. ^{[22
,23
]}

Villoslada, P.

Paul, F. ^{[20
,24
,25
,26
,27
]}

Iorio, Raffaele ^{[28
]}

Paul, Friedemann ^{[29
]}

Wuerfel, Jens ^{[29
,62
]}

Cabre, Philippe ^{[30
]}

Marignier, Romain ^{[31
]}

de Seze, Jerome ^{[32
]}

Tenembaum, Silvia ^{[33
]}

Villoslada, Pablo ^{[34
]}

Levy, Michael ^{[35
]}

Chitnis, Tanuja ^{[36
]}

Klawiter, Eric C. ^{[36
]}

Wingerchuk, Dean ^{[37
]}

Weinshenker, Brian ^{[37
]}

Kim, Ho Jin ^{[38
]}

Pandit, Lekha ^{[39
]}

Leite, Maria Isabel ^{[40
]}

Palace, Jacqueline ^{[40
]}

Simon, Jack ^{[41
,42
]}

Apiwattanakul, Metha ^{[43
]}

Kleiter, Ingo ^{[44
]}

Broadley, Simon ^{[45
]}

Prayoonwiwat, Naraporn ^{[46
]}

Han, May ^{[47
]}

Hellwig, Kerstin ^{[48
]}

Banwell, Brenda ^{[49
]}

van Herle, Katja ^{[50
]}

John, Gareth ^{[51
]}

Hooper, D. Craig ^{[52
]}

Fujihara, Kazuo ^{[53
]}

机构：

[1] Univ Colorado, Dept Neurol, Denver, CO 80202 USA

[2] Univ Colorado, Dept Ophthalmol, Denver, CO 80202 USA

[3] Univ Hosp Strasbourg, Neurol Serv, Strasbourg, France

[4] Univ Fed Minas Gerais, Sch Med, CIEM MS Res Ctr, Belo Horizonte, MG, Brazil

[5] Natl Hlth Serv Trust, Oxford Univ Hosp, Dept Neurol, Oxford, England

[6] Univ Penn, Childrens Hosp Philadelphia, Dept Pediat, Div Neurol, Philadelphia, PA 19104 USA

[7] Univ Zurich Hosp, Dept Neurol, Neuroimmunol & Multiple Sclerosis Res Sect, Zurich, Switzerland

[8] Natl Pediat Hosp Dr Juan P Garrahan, Dept Neurol, Buenos Aires, DF, Argentina

[9] Univ Texas SW Med Ctr Dallas, Dept Neurol, Dallas, TX 75390 USA

[10] Univ Texas SW Med Ctr Dallas, Dept Neurotherapeut, Dallas, TX 75390 USA

[11] Johns Hopkins Univ, Dept Neurol, Baltimore, MD 21218 USA

[12] Tohoku Univ, Grad Sch Med, Dept Multiple Sclerosis Therapeut, Sendai, Miyagi 980, Japan

[13] Univ Hong Kong, LKS Fac Med, Univ Dept Med, Hong Kong, Hong Kong, Peoples R China

[14] Natl Canc Ctr, Res Inst & Hosp, Goyang, South Korea

[15] Univ Southern Denmark, Inst Mol Med, Odense, Denmark

[16] Vejle Hosp, Dept Neurol, Odense, Denmark

[17] Tohoku Univ, Sch Med, Dept Neurol, Sendai, Miyagi 980, Japan

[18] Hosp Clin Barcelona, Serv Neurol, Ctr Neuroimmunol, Barcelona, Spain

[19] Inst Biomed Res August Pi Sunyer, Barcelona, Spain

[20] Charite Univ Med Berlin, NeuroCure Clin Res Ctr, Berlin, Germany

[21] Univ Med Gottingen, Inst Intervent & Diagnost Neuroradiol, Gottingen, Germany

[22] UCSF Dept Neurol, Multiple Sclerosis Ctr, San Francisco, CA USA

[23] UCSF Dept Ophthalmol, Neuroophthalmol Serv, San Francisco, CA USA

[24] Charite, NeuroCure Clin Res, D-13353 Berlin, Germany

[25] Charite, Dept Neurol, D-13353 Berlin, Germany

[26] Charite, Expt & Clin Res Ctr, D-13353 Berlin, Germany

[27] Max Delbruck Ctr Mol Med, Berlin, Germany

[28] Catholic Univ, Rome, Italy

[29] Charite, Berlin, Germany

[30] CHU Ft France, Martinique, France

[31] CHU Lyon, Lyon, France

[32] CHU Strasbourg, Strasbourg, France

[33] Dr Juan P Garrahan Natl Pediat Hosp, Buenos Aires, DF, Argentina

[34] IDIBAPS, Barcelona, Spain

[35] Johns Hopkins Univ, Baltimore, MD USA

[36] Massachusetts Gen Hosp, Boston, MA USA

[37] Mayo Clin, Scottsdale, AZ USA

[38] Res Inst & Hosp Natl Canc Ctr, Goyang, South Korea

[39] Nitte Univ, Mangalore, India

[40] Oxford Univ Hosp, Natl Hlth Serv Trust, Oxford, England

[41] Portland VA Med Ctr, VA Med Ctr, Portland, OR USA

[42] Oregon Hlth & Sci Univ, Portland, OR USA

[43] Prasat Neurol Inst, Bangkok, Thailand

[44] Ruhr Univ Bochum, Bochum, Germany

[45] Griffith Univ, Sch Med, Nathan, Qld 4111, Australia

[46] Mahidol Univ, Siriraj Hosp, Bangkok, Thailand

[47] Stanford Univ, Sch Med, Palo Alto, CA USA

[48] St Josef Hosp, Bochum, Germany

[49] Childrens Hosp Philadelphia, Philadelphia, PA USA

[50] Guthy Jackson Charitable Fdn, San Diego, CA USA

来源：

MULTIPLE SCLEROSIS JOURNAL | 2015年 / 21卷 / 06期

关键词：

Neuromyelitis optica; optical coherence tomography; multiple sclerosis; optic neuritis; retinal nerve fiber layer; ganglion cell layer; NERVE-FIBER LAYER; MICROCYSTIC MACULAR EDEMA; INTERFERON-BETA TREATMENT; INNER NUCLEAR LAYER; GANGLION-CELL; RETINAL ABNORMALITIES; AQUAPORIN; NEURITIS; THICKNESS; SPECTRUM;

D O I：

10.1177/1352458514567216

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Neuromyelitis optica (NMO) is an inflammatory autoimmune disease of the central nervous system that preferentially targets the optic nerves and spinal cord. The clinical presentation may suggest multiple sclerosis (MS), but a highly specific serum autoantibody against the astrocytic water channel aquaporin-4 present in up to 80% of NMO patients enables distinction from MS. Optic neuritis may occur in either condition resulting in neuro-anatomical retinal changes. Optical coherence tomography (OCT) has become a useful tool for analyzing retinal damage both in MS and NMO. Numerous studies showed that optic neuritis in NMO typically results in more severe retinal nerve fiber layer (RNFL) and ganglion cell layer thinning and more frequent development of microcystic macular edema than in MS. Furthermore, while patients' RNFL thinning also occurs in the absence of optic neuritis in MS, subclinical damage seems to be rare in NMO. Thus, OCT might be useful in differentiating NMO from MS and serve as an outcome parameter in clinical studies.

引用

页码：678 / 688

页数：11

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