Quantitative techniques in 18FDG PET scanning in oncology

被引：58

作者：

Castell, F. ^{[2
]}

Cook, G. J. R. ^{[1
]}

机构：

[1] Royal Marsden NHS Fdn Trust, Dept Nucl Med & PET, Sutton SM2 5PT, Surrey, England

[2] Royal Marsden NHS Fdn Trust, Dept Radiotherapy, Sutton SM2 5PT, Surrey, England

来源：

BRITISH JOURNAL OF CANCER | 2008年 / 98卷 / 10期

关键词：

(18)FDG; PET; oncology; quantitation; kinetic analysis;

D O I：

10.1038/sj.bjc.6604330

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The clinical applications of F-18-fluoro-2-deoxyglucose ((18)FDG) positron emission tomography (PET) in oncology are becoming established. While simple static scanning techniques are used for the majority of routine clinical examinations, increasing use of PET in clinical trials to monitor treatment response with (18)FDG and novel tracers reflecting different pharmacodynamic end points, often necessitates a more complex and quantitative analysis of radiopharmaceutical kinetics. A wide range of PET analysis techniques exist, ranging from simple visual analysis and semiquantitative methods to full dynamic studies with kinetic analysis. These methods are discussed, focusing particularly on the available methodologies that can be utilised in clinical trials.

引用

页码：1597 / 1601

页数：5

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