Restrictions to the adaptation of influenza A virus H5 hemagglutinin to the human host

被引：53

作者：

Harvey, R

Martin, ACR

Zambon, M

Barclay, WS

机构：

[1] Univ Reading, Sch Anim & Microbial Sci, Reading RG6 6AJ, Berks, England

[2] Hlth Protect Agcy, Enter & Resp Virus Lab, London NW9 5HT, England

来源：

JOURNAL OF VIROLOGY | 2004年 / 78卷 / 01期

关键词：

D O I：

10.1128/JVI.78.1.502-507.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The binding specificities of a panel of avian influenza virus subtype H5 hemagglutinin (RA) proteins bearing mutations at key residues in the receptor binding site were investigated. The results demonstrate that two simultaneous mutations in the receptor binding site resulted in H5 RA binding in a pattern similar to that shown by human viruses. Coexpression of the ion channel protein, M2, from most avian and human strains tested protected H5 RA conformation during trafficking, indicating that no genetic barrier to the reassortment of the H5 surface antigen gene with internal genes of human viruses existed at this level.

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收藏

页码：502 / 507

页数：6

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