Applications of Baylis-Hillman acetates:: one-pot, facile and convenient synthesis of substituted γ-lactams

被引：79

作者：

Basavaiah, D ^{[1
]}

Rao, JS ^{[1
]}

机构：

[1] Univ Hyderabad, Sch Chem, Hyderabad 500046, Andhra Pradesh, India

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 08期

关键词：

Baylis-Hillman chemistry; gamma-lactams; reductive cyclization; Fe/AcOH;

D O I：

10.1016/j.tetlet.2003.12.133

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple, convenient and one-pot transformation of the acetates of Baylis-Hillman adducts into substituted gamma-lactams, that is, (E)-5-alkyl-3-arylidenepyrrolidin-2-ones via treatment with nitroalkanes in the presence of a base, followed by reductive cyclization, using Fe/AcOH, is described. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：1621 / 1625

页数：5

共 71 条

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