Loss of Function of the GdpP Protein Leads to Joint β-Lactam/Glycopeptide Tolerance in Staphylococcus aureus

被引：80

作者：

Griffiths, J. M.

O'Neill, A. J. ^{[1
]}

机构：

[1] Univ Leeds, Antimicrobial Res Ctr, Leeds, W Yorkshire, England

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2012年 / 56卷 / 01期

基金：

英国医学研究理事会;

关键词：

IDENTIFICATION; VIRULENCE;

D O I：

10.1128/AAC.05148-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The genetic basis of tolerance to inhibitors of peptidoglycan biosynthesis in Staphylococcus aureus was investigated by generating tolerant mutants in vitro and characterizing them by comparative genome sequencing. Two independently selected tolerant mutants harbored nonsynonymous mutations in gdpP, a gene encoding a putative membrane-located signaling protein. Insertional inactivation of gdpP also conferred tolerance. Our findings further implicate altered signal transduction as a route to antibiotic tolerance in S. aureus.

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收藏

页码：579 / 581

页数：3

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