Mutations in the gyrA, parC, and parE genes associated with fluoroquinolone resistance in clinical isolates of Mycoplasma hominis

被引：69

作者：

Bebear, CM

Renaudin, J

Charron, A

Renaudin, H

de Barbeyrac, B

Schaeverbeke, T

Bebear, C

机构：

[1] Univ Bordeaux 2, Bacteriol Lab, F-33076 Bordeaux, France

[2] Inst Natl Rech Agronom, Biol Cellulaire & Mol Lab, F-33883 Villenave Dornon, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1999年 / 43卷 / 04期

关键词：

D O I：

10.1128/AAC.43.4.954

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Five clinical isolates of Mycoplasma hominis from three different patients were examined for resistance to fluoroquinolones; some of these isolates were probably identical. All five isolates harbored amino acid substitutions in the quinolone resistance determining regions of both DNA gyrase (GyrA) and topoisomerase IV (ParC or ParE), Furthermore, the novobiocin MIC for three isolates showed a significant increase. This is the first characterization of fluoroquinolone-resistant clinical mycoplasma isolates from humans.

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页码：954 / 956

页数：3

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