Tec kinases: modulators of lymphocyte signaling and development

被引：84

作者：

Lewis, CM

Broussard, C

Czar, MJ

Schwartzberg, PL

机构：

[1] NIH, Natl Human Genome Res Inst, Bethesda, MD 20892 USA

[2] NIH, Howard Hughes Med Inst, Res Scholars Program, Bethesda, MD 20892 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2001年 / 13卷 / 03期

关键词：

D O I：

10.1016/S0952-7915(00)00221-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The Tec kinases are implicated as important components of the antigen receptor signaling required for proper lymphocyte activation and development. Recent data suggest that these kinases contribute to multiprotein complexes containing LAT and SLP-76 in T cells, and BLNK/SLP-65 in B cells, which are required for activation of PLC-gamma and downstream pathways.

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页码：317 / 325

页数：9

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