The VP3 gene of human group C rotavirus

被引：2

作者：

SamarbafZadeh, AR ^{[1
]}

Lambden, PR ^{[1
]}

Green, SM ^{[1
]}

Deng, Y ^{[1
]}

Caul, EO ^{[1
]}

Clarke, IN ^{[1
]}

机构：

[1] REG VIRUS LAB,BRISTOL BS2 8EL,AVON,ENGLAND

来源：

VIRUS GENES | 1996年 / 13卷 / 02期

关键词：

rotavirus; dsRNA; VP3; gene;

D O I：

10.1007/BF00568909

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The complete nucleotide sequence of genome segment 4 from the human group C rotavirus (Bristol strain) was determined. Comparison of the nucleotide sequences of the genome termini with the consensus 5' and 3' terminal non-coding sequences of the human group C rotavirus genome revealed characteristic 5' and 3' sequence motifs. Human group C rotavirus genome segment 4 is 2,166bp long and encodes a single open reading frame of 2,082 nucleotides (693 amino acids) starting at nucleotide 55 and terminating at nucleotide 2,136 giving a 3' untranslated region of 30 nucleotides. Alignment with the porcine group C VP3 equivalent gene showed the human gene is one amino acid longer, and that the proteins have 84.1% amino acid sequence identity. A conserved potential nucleotide binding motif shared with the porcine VP3 sequence was identified. Analogy with the group A rotaviruses suggested that the genome segment 4 encodes the group C rotavirus guanylyltransferase.

引用

页码：169 / 173

页数：5

共 21 条

[1] SEQUENCES OF THE 4 LARGER PROTEINS OF A PORCINE GROUP-C ROTAVIRUS AND COMPARISON WITH THE EQUIVALENT GROUP-A ROTAVIRUS PROTEINS [J].