A new nonparametric linkage statistic for mapping both qualitative and quantitative trait loci

被引：7

作者：

Camp, NJ ^{[1
]}

Gutin, A ^{[1
]}

Abkevich, V ^{[1
]}

Farnham, JM ^{[1
]}

Cannon-Albright, L ^{[1
]}

Thomas, A ^{[1
]}

机构：

[1] Univ Utah, Dept Genet Epidemiol, Myriad Genet Inc, Salt Lake City, UT 84108 USA

来源：

GENETIC EPIDEMIOLOGY | 2001年 / 21卷

关键词：

linkage; nonparametric; qualitative; quantitative;

D O I：

10.1002/gepi.2001.21.s1.s461

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We describe an alternative nonparametric linkage (NPL) statistic to that of Kruglyak et al. [Am. J. Hum. Genet. 58:1347-63, 1996] that can be used with qualitative phenotypes, and is easily extended for use with quantitative phenotypes. We analyzed the Genetic Analysis Workshop 12 simulated isolated population data, replicate 1, using two phenotypes; affected status (AFF) a dichotomous phenotype and quantitative trait Q5, which was chosen since it was the most strongly associated with AFF. One false positive significant NPL score was observed for the AFF phenotype. For Q5 a single region on chromosome I reached genome-wide significance. The peak of this signal was for marker D01G137 at 135.1 cM with a quantitative trait locus (QTL)-NPL score of 4.19. The nearest marker to the true location of the major gene (MG5 at 137.1 cM) was D01G139 at position 135.8 cM, where the QTL-NPL score was still high at 4.08. ((C)) 2001 Wiley-Liss, Inc.

引用

页码：S461 / S466

页数：6

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