Synthesis of carbocyclic NAD(+) containing a methylenebisphosphonate linkage for the investigation of ADP-ribosyl cyclase

被引：17

作者：

Hutchinson, EJ ^{[1
]}

Taylor, BF ^{[1
]}

Blackburn, GM ^{[1
]}

机构：

[1] UNIV SHEFFIELD,DEPT CHEM,KREBS INST BIOMOL SCI,SHEFFIELD S3 7HF,S YORKSHIRE,ENGLAND

来源：

CHEMICAL COMMUNICATIONS | 1996年 / 24期

关键词：

D O I：

10.1039/cc9960002765

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A stereospecific synthesis of carbocyclic NAD(+) incorporating a methylenebisphosphonatelinkage in place of the natural pyrophosphate gives an analogue 4 of the natural coenzyme NAD(+) 3a designed to act as an inhibitor of ADP-ribosyl cyclase and to resist non-specific phosphatase degradation.

引用

页码：2765 / 2766

页数：2

共 26 条

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