Synthesis of carbocyclic NAD(+) containing a methylenebisphosphonate linkage for the investigation of ADP-ribosyl cyclase

被引:17
作者
Hutchinson, EJ [1 ]
Taylor, BF [1 ]
Blackburn, GM [1 ]
机构
[1] UNIV SHEFFIELD,DEPT CHEM,KREBS INST BIOMOL SCI,SHEFFIELD S3 7HF,S YORKSHIRE,ENGLAND
关键词
D O I
10.1039/cc9960002765
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A stereospecific synthesis of carbocyclic NAD(+) incorporating a methylenebisphosphonatelinkage in place of the natural pyrophosphate gives an analogue 4 of the natural coenzyme NAD(+) 3a designed to act as an inhibitor of ADP-ribosyl cyclase and to resist non-specific phosphatase degradation.
引用
收藏
页码:2765 / 2766
页数:2
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