Fluorine substituent effects (on bioactivity)

被引：1399

作者：

Smart, BE ^{[1
]}

机构：

[1] DuPont Co Inc, Cent Res & Dev, Expt Stn, Wilmington, DE 19880 USA

来源：

JOURNAL OF FLUORINE CHEMISTRY | 2001年 / 109卷 / 01期

关键词：

fluorocarbon volatility; lipophilicity; solubility; acidity and basicity; fluorine steric effects;

D O I：

10.1016/S0022-1139(01)00375-X

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The characteristic effects of fluorine and fluoroalkyl substituents on the physico-chemical properties of molecules that are important to biological activity of fluorinated compounds are highlighted. The influence of fluorination on acidity, hydrogen-bonding, and lipophilicity that affect compound absorption and distribution is described. The current perspectives on fluorine steric interactions and the controversial role of hydrogen-bonding involving the C-F bond are discussed. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：3 / 11

页数：9

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