Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia II: Developing Imaging Biomarkers to Enhance Treatment Development for Schizophrenia and Related Disorders

被引：44

作者：

Carter, Cameron S. ^{[1
]}

Barch, Deanna M. ^{[2
,3
]}

Bullmore, Edward T. ^{[4
]}

Breiling, James ^{[5
]}

Buchanan, Robert W. ^{[6
]}

Butler, Pamela ^{[7
]}

Cohen, Jonathan D. ^{[8
]}

Geyer, Mark ^{[9
]}

Gollub, Randy ^{[10
]}

Green, Michael F. ^{[11
,12
]}

Jaeger, Judith ^{[13
]}

Krystal, John H. ^{[14
]}

Moore, Holly ^{[15
]}

Nuechterlein, Keith ^{[16
]}

Robbins, Trevor ^{[4
]}

Silverstein, Steven ^{[17
]}

Smith, Edward E. ^{[15
]}

Strauss, Milton ^{[18
]}

Wykes, Til ^{[19
]}

机构：

[1] Univ Calif Davis, UC Davis Imaging Res Ctr, Dept Psychiat, Sacramento, CA 95816 USA

[2] Washington Univ, Dept Psychol, St Louis, MO 63130 USA

[3] Washington Univ, Dept Psychiat, St Louis, MO USA

[4] Univ Cambridge, Dept Psychiat, Cambridge, England

[5] NIMH, Bethesda, MD 20892 USA

[6] Univ Maryland, Sch Med, Dept Psychiat, Maryland Psychiat Res Ctr, Baltimore, MD 21201 USA

[7] SUNY, Dept Psychiat, New York, NY USA

[8] Princeton Univ, Dept Psychol, Princeton, NJ 08544 USA

[9] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA

[10] Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA

[11] Univ Calif Los Angeles, Dept Psychiat, Semel Inst, Los Angeles, CA USA

[12] VA Greater Los Angeles Healthcare Syst, Los Angeles, CA USA

[13] AstraZeneca, Wilmington, DE USA

[14] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA

[15] Columbia Univ, Dept Psychiat, New York, NY USA

[16] Univ Calif Los Angeles, Dept Psychiat, Los Angeles, CA USA

[17] Univ Med & Dent New Jersey, Dept Psychiat, Newark, NJ 07103 USA

[18] Univ New Mexico, Dept Psychiat, Albuquerque, NM 87131 USA

[19] Kings Coll London, Inst Psychiat, London WC2R 2LS, England

来源：

BIOLOGICAL PSYCHIATRY | 2011年 / 70卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Biomarker; CNTRICS; cognition; schizophrenia; treatment;

D O I：

10.1016/j.biopsych.2011.01.041

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia (CNTRICS) initiative, funded by an R13 from the National Institute of Mental Health, seeks to enhance translational research in treatment development for impaired cognition in schizophrenia by developing tools from cognitive neuroscience into useful measures of treatment effects on behavior and brain function. An initial series of meetings focused on the selection of a new set of tasks from cognitive neuroscience for the measurement of treatment effects on specific cognitive and neural systems. Subsequent validation and optimization studies are underway and a subset of validated measures with well-characterized psychometric properties will be generally available in 2011. This article describes results of the first meeting of the second phase of the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia, which seeks to develop imaging biomarkers and improved animal models to enhance translational research. In this meeting, we considered issues related to the use of methods such as functional magnetic resonance imaging, electroencephalography, magnetoencephalography, and transcranial magnetic simulation as biomarkers for treatment development. We explored the biological nature of the signals measured by each method, their validity and reliability as measures of cognition-related neural activity, potential confounds related to drug effects on the signal of interest, and conceptual, methodological, and pragmatic issues related to their use in preclinical, first into human, and multicenter phase II and III studies. This overview article describes the background and goals of the meeting together with a summary of the major issues discussed in more detail in the accompanying articles appearing in this issue of Biological Psychiatry.

引用

页码：7 / 12

页数：6

共 10 条

[1] How We Say No: Norepinephrine, Inferior Frontal Gyrus, and Response Inhibition [J].

Aston-Jones, Gary ;

Gold, Joshua I. .

BIOLOGICAL PSYCHIATRY, 2009, 65 (07) :548-549

[2] Measurement issues in the use of cognitive neuroscience tasks in drug development for impaired cognition in schizophrenia: A report of the second consensus building conference of the CNTRICS initiative [J].

Barch, Deanna M. ;

Carter, Cameron S. .

SCHIZOPHRENIA BULLETIN, 2008, 34 (04) :613-618

[3] Selecting Paradigms From Cognitive Neuroscience for Translation into Use in Clinical Trials: Proceedings of the Third CNTRICS Meeting [J].

Barch, Deanna M. ;

Carter, Cameron S. ;

Arnsten, Amy ;

Buchanan, Robert W. ;

Cohen, Jonathan D. ;

Geyer, Mark ;

Green, Michael F. ;

Krystal, John H. ;

Nuechterlein, Keith ;

Robbins, Trevor ;

Silverstein, Steven ;

Smith, Edward E. ;

Strauss, Milton ;

Wykes, Til ;

Heinssen, Robert .

SCHIZOPHRENIA BULLETIN, 2009, 35 (01) :109-114

[4]

BARCH DM, 2011, BIOL PSYCHIAT, V70

[5] Endophenotypes: Bridging Genomic Complexity and Disorder Heterogeneity [J].

Insel, Thomas R. ;

Cuthbert, Bruce N. .

BIOLOGICAL PSYCHIATRY, 2009, 66 (11) :988-989

[6] A Roadmap for the Development and Validation of Event-Related Potential Biomarkers in Schizophrenia Research [J].

Luck, Steven J. ;

Mathalon, Daniel H. ;

O'Donnell, Brian F. ;

Hamalainen, Matti S. ;

Spencer, Kevin M. ;

Javitt, Daniel C. ;

Uhlhaas, Peter J. .

BIOLOGICAL PSYCHIATRY, 2011, 70 (01) :28-34

[7] Applications of fMRI in translational medicine and clinical practice [J].

Matthews, Paul M. ;

Honey, Garry D. ;

Bullmore, Edward T. .

NATURE REVIEWS NEUROSCIENCE, 2006, 7 (09) :732-744

[8] Transcranial Magnetic Stimulation: A Neuroscientific Probe of Cortical Function in Schizophrenia [J].

McClintock, Shawn M. ;

Freitas, Catarina ;

Oberman, Lindsay ;

Lisanby, Sarah H. ;

Pascual-Leone, Alvaro .

BIOLOGICAL PSYCHIATRY, 2011, 70 (01) :19-27

[9] The quest for developing new treatments from imaging techniques: promises, problems and future potential [J].

Minzenberg, Michael J. ;

Carter, Cameron S. .

EXPERT OPINION ON DRUG DISCOVERY, 2007, 2 (08) :1029-1033

[10] Modanfinil Shifts Human Locus Coeruleus to Low-Tonic, High-Phasic Activity During Functional MRI [J].

Minzenberg, Michael J. ;

Watrous, Andrew J. ;

Yoon, Jong H. ;

Ursu, Stefan ;

Carter, Cameron S. .

SCIENCE, 2008, 322 (5908) :1700-1702

← 1 →