Peripheral inflammation reduces the response of spinal dorsal horn neurons to an NK3 receptor agonist

被引：6

作者：

Ackley, MA ^{[1
]}

Asghar, AUR ^{[1
]}

Worsley, MA ^{[1
]}

King, AE ^{[1
]}

机构：

[1] Univ Leeds, Sch Biomed Sci, Leeds LS2 9NQ, W Yorkshire, England

来源：

NEUROSCIENCE LETTERS | 2001年 / 308卷 / 01期

基金：

英国惠康基金;

关键词：

neurokinins; NK3; neurokinin B; inflammation; carrageenan; dorsal horn;

D O I：

10.1016/S0304-3940(01)01968-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The neurokinin receptors NK1 and NK3 are involved in processing nociceptive information in the spinal dorsal horn and in central changes following persistent peripheral injury. However, little is known about functional changes in these receptor systems, particularly the NK3 receptor. We have performed intracellular recordings from spinal dorsal horn neurons in vitro, using spinal cords obtained both from control rats and from those with a peripheral inflammation induced by carrageenan. Application of the NK1 receptor agonist, [Sar(9), Met(O-2)(11)]Substance P and the NK3 receptor agonist Senktide, produced slow, long lasting depolarizations. The Senktide- but not [Sar(9), Met(O-2)(11)]Substance P-induced depolarizations were significantly smaller in carrageenan-treated rats. These data indicate an altered role for the NK3 receptor in the spinal dorsal horn following acute peripheral inflammation. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：13 / 16

页数：4

共 20 条

[1]

Abbadie C, 1997, J NEUROSCI, V17, P8049

[2]

ACKLEY MA, 1998, THESIS U LEEDS

[3] The anticonvulsant remacemide and its metabolite AR-R12495AA attenuate spinal synaptic transmission and carrageenan-induced inflammation in the young rat [J].

Asghar, AUR ;

Hasan, SS ;

King, AE .

EUROPEAN JOURNAL OF PAIN-LONDON, 2000, 4 (01) :97-106

[4]

Baba H, 1999, J NEUROSCI, V19, P859

[5] Altered nociception, analgesia and aggression in mice lacking the receptor for substance P [J].

De Felipe, C ;

Herrero, JF ;

O'Brien, JA ;

Palmer, JA ;

Doyle, CA ;

Smith, AJH ;

Laird, JMA ;

Belmonte, C ;

Cervero, F ;

Hunt, SP .

NATURE, 1998, 392 (6674) :394-397

[6] Tachykinin actions on deep dorsal horn neurons in vitro: An electrophysiological and morphological study in the immature rat [J].

King, AE ;

Slack, JR ;

LopezGarcia, JA ;

Ackley, MA .

EUROPEAN JOURNAL OF NEUROSCIENCE, 1997, 9 (05) :1037-1046

[7]

KWATRA MM, 1993, J BIOL CHEM, V268, P9161

[8] CHARACTERIZATION OF THE EFFECTS PRODUCED BY NEUROKININS AND 3 AGONISTS SELECTIVE FOR NEUROKININ RECEPTOR SUBTYPES IN A SPINAL NOCICEPTIVE REFLEX OF THE RAT [J].

LANEUVILLE, O ;

DORAIS, J ;

COUTURE, R .

LIFE SCIENCES, 1988, 42 (13) :1295-1305

[9] Time-dependent changes in neurokinin3 receptors and tachykinins during adjuvant-induced peripheral inflammation ln the rat [J].

Linden, DR ;

Reutter, MA ;

McCarson, KE ;

Seybold, VS .

NEUROSCIENCE, 2000, 98 (04) :801-811

[10] Spinal neurokinin3 receptors mediate thermal but not mechanical hyperalgesia via nitric oxide [J].

Linden, DR ;

Seybold, VS .

PAIN, 1999, 80 (1-2) :309-317

← 1 2 →