HTTM, a horizontally transferred transmembrane domain

被引：19

作者：

Schultz, J ^{[1
]}

机构：

[1] Max Planck Inst Mol Genet, D-14195 Berlin, Germany

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2004年 / 29卷 / 01期

关键词：

D O I：

10.1016/j.tibs.2003.11.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sequence analysis of vitamin K-dependent gamma-carboxylases (VKGC) has revealed the presence of a novel domain, HTTM (for horizontally transferred transmembrane) in its N terminus. In contrast to most known domains, HTTM contains four transmembrane regions. Its occurrence in eukaryotes, bacteria and archaea is probably caused by horizontal gene transfer rather than by early evolution. The conservation of VKGC. catalytic sites also indicates an enzymatic function for the other family members.

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页码：4 / 7

页数：4

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