DNA repair: The importance of phosphorylating histone H2AX

被引：155

作者：

Lowndes, NF ^{[1
]}

Toh, GWL

机构：

[1] Natl Univ Ireland Univ Coll Galway, Dept Biochem, Genome Stabil Lab, Galway, Ireland

[2] Natl Univ Ireland Univ Coll Galway, Natl Ctr Biomed Engn Sci, Galway, Ireland

来源：

CURRENT BIOLOGY | 2005年 / 15卷 / 03期

关键词：

D O I：

10.1016/j.cub.2005.01.029

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

How phosphorylated histone H2AX, known as gamma-H2AX, functions in the cellular response to DNA double-strand breaks is the subject of intensive investigation. Recent research in yeast and mammalian cells shows that gamma-H2AX facilitates post-replicational DNA repair by recruiting cohesin, a protein complex that holds sister chromatids together.

引用

页码：R99 / R102

页数：4

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