Antitumor-promoting effects of cyclic diarylheptanoids on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis

被引：56

作者：

Ishida, J

Kozuka, M

Wang, HK

Konoshima, T

Tokuda, H

Okuda, M

Mou, XY

Nishino, H

Sakurai, N

Lee, KH ^{[1
]}

Nagai, M

机构：

[1] Univ N Carolina, Sch Pharm, Nat Prod Lab, Chapel Hill, NC 27599 USA

[2] Kyoto Pharmaceut Univ, Yamashina Ku, Kyoto 6078414, Japan

[3] Kyoto Prefectural Univ Med, Dept Biochem, Kamigyo Ku, Kyoto 6020841, Japan

[4] Hoshi Univ, Shinagawa Ku, Tokyo 142, Japan

来源：

CANCER LETTERS | 2000年 / 159卷 / 02期

关键词：

antitumor-promoting effect; Epstein-Barr virus activation test; two-stags skin carcinogenesis test; cyclic diaryl heptanoids; myricanone;

D O I：

10.1016/S0304-3835(00)00538-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Eleven cyclic diarylheptanoids were screened as potential antitumor promoters by examining the ability of the compounds to inhibit Epstein-Barr virus early antigen activation (induced by 12-O-tetradecanoylphorbol-13-acetate) in Raji cells. 13-Oxomyricanol and myricanone showed the highest activity and also exhibited remarkable inhibitory effects on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. These data suggest that certain diarylheptanoids might be valuable antitumor promoters and/or chemopreventors. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：135 / 140

页数：6

共 14 条

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