An improved synthesis of N-aryl-hydantoin LFA-1 antagonists via the enantiospecific alkylation of an isobutyraldehyde-derived imidazolidinone template

被引：27

作者：

Frutos, RP ^{[1
]}

Stehle, S ^{[1
]}

Nummy, L ^{[1
]}

Yee, N ^{[1
]}

机构：

[1] Boehringer Ingelheim Pharmaceut Inc, Dept Chem Dev, Ridgefield, CT 06877 USA

来源：

TETRAHEDRON-ASYMMETRY | 2001年 / 12卷 / 01期

关键词：

D O I：

10.1016/S0957-4166(01)00009-X

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

An improved and cost-effective process for the synthesis of N-aryl-hydantoin LFA-1 antagonists is described. Key transformations include the synthesis and stereospecific alkylation of the trans-isobutyraldehyde-derived template 4, and the one-pot hydrolysis of intermediate 6. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：101 / 104

页数：4

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