Homing markers for atherosclerosis: applications for drug delivery, gene delivery and vascular imaging

被引：30

作者：

Houston, P ^{[1
]}

Goodman, J ^{[1
]}

Lewis, A ^{[1
]}

Campbell, CJ ^{[1
]}

Braddock, M ^{[1
]}

机构：

[1] Glaxo Wellcome Med Res Ctr, Cardiovasc Syst Unit, Stevenage SG1 2NY, Herts, England

来源：

FEBS LETTERS | 2001年 / 492卷 / 1-2期

关键词：

atherosclerosis; homing markers; gene delivery; drug delivery; vascular imaging;

D O I：

10.1016/S0014-5793(01)02191-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Endothelial dysfunction plays a major role in the pathogenesis of atherosclerosis. Pro-inflammatory cytokines such as interleukin-1 beta and tumour necrosis factor alpha activate endothelial cells changing their resting phenotype to become pro-adhesive, pro-thrombotic and pro-atherogenic. Phage display in vivo biopanning has been used to identify peptide sequences that home to diseased regions of the vessel wall in low density lipoprotein receptor (LDLr) knockout mice. In LDLr knockout mice, peptide sequence determinants exhibiting organ specificity have been isolated. These sequences have applications for gene delivery, drug delivery and for improving contrast agents for vascular imaging. (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：73 / +

页数：6

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