Signaling and endocytosis: A team effort for cell migration

被引：46

作者：

Le Roy, C ^{[1
]}

Wrana, JL ^{[1
]}

机构：

[1] Univ Toronto, Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Dept Med Genet & Microbiol,Ctr Syst Biol, Toronto, ON M5G 1X5, Canada

来源：

DEVELOPMENTAL CELL | 2005年 / 9卷 / 02期

关键词：

D O I：

10.1016/j.devcel.2005.07.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cellular movement from one place to another is regulated by various guidance cues. The precise perception of these signals in the three-dimensional environment of a multicellular organism is remarkably complex. Recent work is now revealing that guided cell movement also requires spatial control of signaling events by endocytic dynamics.

引用

收藏

页码：167 / 168

页数：2

相关论文

共 7 条

[1] COMPARTMENTALIZATION OF SHC, GRB2 AND MSOS, AND HYPERPHOSPHORYLATION OF RAF-1 BY EGF BUT NOT INSULIN IN LIVER PARENCHYMA [J].

DIGUGLIELMO, GM ;

BAASS, PC ;

OU, WJ ;

POSNER, BI ;

BERGERON, JJM .

EMBO JOURNAL, 1994, 13 (18) :4269-4277

[2] Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCζ [J].

Etienne-Manneville, S ;

Hall, A .

CELL, 2001, 106 (04) :489-498

[3] Regulators of endocytosis maintain localized receptor tyrosine kinase signaling in guided migration [J].

Jékely, G ;

Sung, HH ;

Luque, CM ;

Rorth, P .

DEVELOPMENTAL CELL, 2005, 9 (02) :197-207

[4] Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling [J].

Le Roy, C ;

Wrana, JL .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2005, 6 (02) :112-126

[5] APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment [J].

Miaczynska, M ;

Christoforidis, S ;

Giner, A ;

Shevchenko, A ;

Uttenweiler-Joseph, S ;

Habermann, B ;

Wilm, M ;

Parton, RG ;

Zerial, M .

CELL, 2004, 116 (03) :445-456

[6] Genome-wide analysis of human kinases in clathrin- and caveolae/raft-mediated endocytosis [J].

Pelkmans, L ;

Fava, E ;

Grabner, H ;

Hannus, M ;

Habermann, B ;

Krausz, E ;

Zerial, M .

NATURE, 2005, 436 (7047) :78-86

[7] Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction [J].

Teis, D ;

Wunderlich, W ;

Huber, LA .

DEVELOPMENTAL CELL, 2002, 3 (06) :803-814