Effects of acutely displaced sleep on testosterone

被引:122
作者
Axelsson, J
Ingre, M
Åkerstedt, T
Holmbäck, U
机构
[1] Natl Inst Psychosocial Med, S-17177 Stockholm, Sweden
[2] Karolinska Inst, S-17177 Stockholm, Sweden
[3] Univ Uppsala, Dept Med Sci Nutr, S-75185 Uppsala, Sweden
关键词
D O I
10.1210/jc.2005-0520
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Context: It is not yet clear whether the diurnal variation in testosterone is regulated by circadian or homeostatic (sleep) influences. Design, Setting, and Participants: In the sleep laboratory, seven healthy young men (age, 22-32 yr) participated in three conditions: habituation (sleep between 2300-0700 h), night sleep (2300-0700 h), and day sleep (0700-1500 h), the latter two in a balanced order.Objective: The present study tested whether testosterone is driven by a circadian-independent sleep effect by shifting sleep acutely to daytime in a 24-h sampling regiment. Intervention and Main Outcome Measure: Serum testosterone was, in all conditions, sampled by hourly blood drawing for 24 h during constant bed rest. Results: Mean testosterone levels increased as a log-linear function of time ( hours) across both sleep periods (b = 4.88; P < 0.001), from 15.3 +/- 2.1 to 25.3 +/- 2.2 nmol/liter during night sleep and from 17.3 +/- 2.1 to 26.4 +/- 2.9 nmol/liter during day sleep. Similarly, mean testosterone levels decreased with time (log-linear) awake (b = -1.80; P < 0.001). There was also evidence of a weak circadian component (acrophase ranging between 0651-0924 h) and an increase with time in the laboratory. Moreover, all these effects, except for the increase during sleep, differed significantly between individuals. Conclusion: In conclusion, testosterone increased during sleep and fell during waking, whereas circadian effects seemed marginal. Individual differences were pronounced.
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页码:4530 / 4535
页数:6
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