Decreasing levels of anti-Nef antibody correlate with increasing HIV type 1 viral loads and AIDS disease progression

被引：11

作者：

Chen, YMA ^{[1
]}

Lin, RH

Lee, CM

Fu, CY

Chen, SC

Syu, WJ

机构：

[1] Natl Yang Ming Univ, Inst Publ Hlth, Sch Med, Div Prevent Med, Taipei 112, Taiwan

[2] Natl Yang Ming Univ, AIDS Prevent & Res Ctr, Taipei 112, Taiwan

[3] Natl Yang Ming Univ, Sch Life Sci, Inst Microbiol & Immunol, Taipei 112, Taiwan

[4] Taipei Venereal Dis Control Inst, Taipei, Taiwan

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 1999年 / 15卷 / 01期

关键词：

D O I：

10.1089/088922299311691

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To study the association between anti-Gag and anti-Nef antibody reactivities and their correlations with disease progression, 174 HIV-1/AIDS patients were followed up for 1 year after they received triple therapy. The antibody reactivities were analyzed using a Western blot test with recombinant Gag and Nef proteins. The results showed that decreasing levels of anti-Gag or anti-Nef antibody correlate with disease progression defined by HIV-1 viral loads or T4 cell counts. After receiving triple treatment for 1 year, 8 of 38 (21.1%) Nef antibody-negative patients became positive, while only 9 of 125 (7.2%) Nef antibody-positive persons lost the antibody reactivity (p < 0.01). Therefore, HIV-1 Nef may serve as a clinical marker of disease progression.

引用

页码：43 / 50

页数：8

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