Photochemical rearrangement of oxaziridines and nitrones in the hexahydroindole series: A convenient synthetic route to 1-azabicyclo[5.2.0]nonan-2-ones as novel RGD mimetics

被引：25

作者：

Bourguet, E

Baneres, JL

Girard, JP

Parello, J

Vidal, JP

Lusinchi, X

Declercq, JP

机构：

[1] Fac Pharm Montpellier, UMR CNRS 5074, Lab Chim Biomol & Interact Biol, F-34060 Montpellier, France

[2] Inst Chim Subst Nat, Gif Sur Yvette, France

[3] Catholic Univ Louvain, Lab Cristallog, B-1348 Louvain, Belgium

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 20期

关键词：

D O I：

10.1021/ol016184j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

GRAPHICS Photolysis of oxaziridines a or nitrones b provides a convenient synthetic route to fused bicyclic lactams c adequately substituted on both cycles A and B as scaffolds for mimicking conformationally constrained beta -turn peptides as in the tripeptide RGD signaling motif of fibronectin.

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收藏

页码：3067 / 3070

页数：4

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