Nitric oxide synthase gene polymorphism and its influence on cardiovascular disease

被引：22

作者：

Soma, M ^{[1
]}

Nakayama, T ^{[1
]}

Kanmatsuse, K ^{[1
]}

机构：

[1] Nihon Univ, Sch Med, Dept Internal Med 2, Ibashi Ku, Tokyo 1738610, Japan

来源：

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION | 1999年 / 8卷 / 01期

关键词：

D O I：

10.1097/00041552-199901000-00013

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Several lines of evidence indicate a significant association between variations of the endothelial constitutive nitric oxide synthase gene and the incidence of cardiovascular disease, and discrepant findings may be attributable to racial differences. The detection of functional allelic polymorphisms may be needed to confirm this association, because direct evidence to support a causative role for the endothelial constitutive nitric oxide synthase gene is not yet available. There are no available data to confirm that neural and inducible nitric oxide synthases are associated with cardiovascular diseases. Curr Opin Nephrol Hypertens 8:83-87. (C) 1999 Lippincott Williams & Wilkins.

引用

页码：83 / 87

页数：5

共 43 条

[1]

Measurement of nitrite and nitrate levels in plasma and urine - what does this measure tell us about the activity of the endogenous nitric oxide system? [J].

Baylis, C ;

Vallance, P .

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION, 1998, 7 (01) :59-62

[2]

SELECTIVE NEURONAL NITRIC-OXIDE SYNTHASE INHIBITION BLOCKS FUROSEMIDE-STIMULATED RENIN SECRETION IN-VIVO [J].

BEIERWALTES, WH .

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL FLUID AND ELECTROLYTE PHYSIOLOGY, 1995, 269 (01) :F134-F139

[3]

LACK OF EVIDENCE FOR LINKAGE OF THE ENDOTHELIAL-CELL NITRIC-OXIDE SYNTHASE GENE TO ESSENTIAL-HYPERTENSION [J].

BONNARDEAUX, A ;

NADAUD, S ;

CHARRU, A ;

JEUNEMAITRE, X ;

CORVOL, P ;

SOUBRIER, F .

CIRCULATION, 1995, 91 (01) :96-102

[4]

LOCALIZATION OF NITRIC-OXIDE SYNTHASE INDICATING A NEURAL ROLE FOR NITRIC-OXIDE [J].

BREDT, DS ;

HWANG, PM ;

SNYDER, SH .

NATURE, 1990, 347 (6295) :768-770

[5]

Burg M, 1997, CLIN NEPHROL, V48, P205

[6]

NITRIC-OXIDE AND ITS PUTATIVE ROLE IN HYPERTENSION [J].

DOMINICZAK, AF ;

BOHR, DF .

HYPERTENSION, 1995, 25 (06) :1202-1211

[7]

Edwards JH, 1997, ANN HUM GENET, V61, P351, DOI 10.1017/S0003480097006271

[8]

Basal nitric oxide synthesis in essential hypertension [J].

Forte, P ;

Copland, M ;

Smith, LM ;

Milne, E ;

Sutherland, J ;

Benjamin, N .

LANCET, 1997, 349 (9055) :837-842

[9]

THE OBLIGATORY ROLE OF ENDOTHELIAL-CELLS IN THE RELAXATION OF ARTERIAL SMOOTH-MUSCLE BY ACETYLCHOLINE [J].

FURCHGOTT, RF ;

ZAWADZKI, JV .

NATURE, 1980, 288 (5789) :373-376

[10]

HYPERTENSION IN MICE LACKING THE GENE FOR ENDOTHELIAL NITRIC-OXIDE SYNTHASE [J].

HUANG, PL ;

HUANG, ZH ;

MASHIMO, H ;

BLOCH, KD ;

MOSKOWITZ, MA ;

BEVAN, JA ;

FISHMAN, MC .

NATURE, 1995, 377 (6546) :239-242

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