The protective effect of immunologic boosting against zoster: An analysis in leukemic children who were vaccinated against chickenpox

被引：75

作者：

Gershon, AA ^{[1
]}

LaRussa, P ^{[1
]}

Steinberg, S ^{[1
]}

Mervish, N ^{[1
]}

Lo, SH ^{[1
]}

Meier, P ^{[1
]}

机构：

[1] COLUMBIA UNIV COLL PHYS & SURG,DEPT EPIDEMIOL,NEW YORK,NY 10032

来源：

JOURNAL OF INFECTIOUS DISEASES | 1996年 / 173卷 / 02期

关键词：

D O I：

10.1093/infdis/173.2.450

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Whether reexposure of varicella-immune persons to varicella-zoster virus would protect against or predispose to development of tester was analyzed. The rate of tester in 511 leukemic recipients of varicella vaccine who had 1 or > 1 dose of varicella vaccine and in those who did or did not have a household exposure to varicella was determined, A Kaplan-Meier life-table analysis revealed that the incidence of tester was lower in those given > 1 dose of vaccine (P < .05), A Cox proportional hazards analysis showed that both household exposure to varicella and receipt of > 1 dose of vaccine were highly protective (P < .01) against tester. Thus, the risk of tester is decreased by reexposure to varicella-zoster virus, either by vaccination or by close exposure to varicella..

引用

页码：450 / 453

页数：4

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