Postnatal changes in nerve growth factor and brain derived neurotrophic factor levels in the retina, visual cortex, and geniculate nucleus in rats with retinitis pigmentosa

被引：38

作者：

Amendola, T ^{[1
]}

Fiore, M ^{[1
]}

Aloe, L ^{[1
]}

机构：

[1] CNR, Ist Neurobiol & Med Mol, I-00137 Rome, Italy

来源：

NEUROSCIENCE LETTERS | 2003年 / 345卷 / 01期

关键词：

nerve growth factor; brain derived neurotrophic factor; neurotrophins; retinitis pigmentosa; visual system;

D O I：

10.1016/S0304-3940(03)00491-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Royal College of Surgeons (RCS) rats are a well established animal model of inherited retinitis pigmentosa (RP). Using RCS rats we examined the distribution of nerve growth factor (NGF) and brain derived neurotrophic factor (BDNF) in the visual cortex, geniculate nucleus and retina at three different postnatal ages. It was found that the retina of rats with RP expresses low amounts of NGF and BDNF in young and adult life. Altered levels of these factors were found in the visual cortex and in the geniculate nucleus. Our findings indicate that NGF and BDNF are differentially affected in the visual system of developing and adult RCS rats, suggesting that neurotrophins may be implicated in the pathogenesis of inherited RP. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：37 / 40

页数：4

共 20 条

[1] Nerve growth factor in neurological and non-neurological diseases: Basic findings and emerging pharmacological prospectives [J].