What are the links between Epstein-Barr virus, lymphoma, and tumor necrosis factor antagonism in rheumatoid arthritis?

被引：20

作者：

Balandraud, N

Roudier, J ^{[1
]}

Roudier, C

机构：

[1] INSERM, Fac Med, UMR 639, Immunogenet RA, F-13005 Marseille, France

[2] Hop La Concept, APHM, Rheumatol Ward, F-13005 Marseille, France

来源：

SEMINARS IN ARTHRITIS AND RHEUMATISM | 2005年 / 34卷 / 05期

关键词：

Epstein-Barr virus; lymphoma; rheumatoid arthritis; tumor necrosis factor inhibitors; methotrexate; EBV load;

D O I：

10.1016/j.semarthrit.2005.01.008

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

EPSTEIN-BARR VIRUS [EBV] AND RHEUMATOID ARTHRITIS [RA] Patients with (RA) have slightly impaired EBV specific immunity. EBV AND LYMPHOMA EBV contributes to the development of lymphoma, especially in immuno-suppressed patients. LYMPHOMA IN RA The incidence of lymphoma is increased (2-fold) in patients with active RA. TUMOR NECROSIS FACTOR (TNF) ANTAGONISM, LYMPHOMA, AND RA The risk to develop lymphoma in patients with RA under TNF inhibitors is slightly higher than that of patients with active RA who do not receive TNF inhibitors. As already demonstrated in the case of posttransplantation lymphoma, EBV load monitoring in patients with RA under TNF inhibitors might allow predicting and preventing the emergence of lymphoma. (c) 2005 Elsevier Inc. All rights reserved.

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页码：31 / 33

页数：3

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