Genetic contribution to male infertility

被引：29

作者：

Chandley, AC ^{[1
]}

机构：

[1] Western Gen Hosp, Dept Urol, Edinburgh EH4 2XU, Midlothian, Scotland

来源：

HUMAN REPRODUCTION | 1998年 / 13卷

关键词：

chromosomes; microdeletions; spermatogenesis; Y chromosome;

D O I：

10.1093/humrep/13.suppl_3.76

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Worldwide, of couples trying for a child, 2-7% fail to conceive, Extensive screening programmes of men attending infertility clinics show that chromosomal and gene disorders make a significant contribution to spermatogenic impairment, It appears that an orderly genome is essential for normal germ cell development, since numerical and structural chromosome abnormalities are found in association with germ cell breakdown, The most recent research indicates that genes on the Y chromosome and autosomes are involved in spermatogenic control.

引用

页码：76 / 83

页数：8

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