Synthesis and pharmacological properties of some quinoline derivatives

被引:173
作者
Kalluraya, B [1 ]
Sreenivasa, S [1 ]
机构
[1] Mangalore Univ, Dept Studies Chem, Mangalagangothri 574199, Karnataka, India
来源
FARMACO | 1998年 / 53卷 / 06期
关键词
thiophene derivatives; anti-inflammatory activity; analgesic activity; anthelmintic activity; quinoline derivatives;
D O I
10.1016/S0014-827X(98)00037-8
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
A series of 2-(2-thienyl)cinchoninic acids 3, their derivatives 5 and 4-(3-substituted-1,2,4-triazolo[3,4-6]-1,3,4-thiadiazolo-6-yl)-2-(2-thienyl) quinolines 6 were synthesized The structures of the newly synthesized compounds are confirmed by analytical, IR, NMR and mass spectral data. The newly synthesized compounds were evaluated for their anti-inflammatory, analgesic and anthelmintic activity. The results indicated that dinitrothiophene derivatives 5 are more active. (C) 1998 Elsevier Science S.A. All rights reserved.
引用
收藏
页码:399 / 404
页数:6
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