Nitric oxide, ischaemia and brain inflammation

被引：44

作者：

Murphy, S. ^{[1
]}

Gibson, C. L.

机构：

[1] Univ Washington, Sch Med, Seattle, WA 98195 USA

[2] Univ Leicester, Sch Psychol, Leicester LE1 9HN, Leics, England

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2007年 / 35卷

关键词：

brain; cerebral ischaemia; inducible nitric oxide synthase (iNOS); inflammation; nitric oxide; progesterone;

D O I：

10.1042/BST0351133

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cerebral ischaemia results in the activation of three isoforms of NOS (nitric oxide synthase) that contribute to the development of and recovery from stroke pathology. This review discusses, in particular, the role of the transcriptionally activated NOS-2 (inducible NOS) isoform and summarizes the outcomes of experimental stroke studies with regard to the therapeutic utility of nitric oxide donors and NOS inhibitors.

引用

收藏

页码：1133 / 1137

页数：5

相关论文

共 49 条

[1] Nitric oxide modulates the catalytic activity of myeloperoxidase [J].

Abu-Soud, HM ;

Hazen, SL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (08) :5425-5430

[2] Nitric oxide synthases: structure, function and inhibition [J].

Alderton, WK ;

Cooper, CE ;

Knowles, RG .

BIOCHEMICAL JOURNAL, 2001, 357 (03) :593-615

[3] L-arginine levels in blood as a marker of nitric oxide-mediated brain damage in acute stroke:: A clinical and experimental study [J].

Armengou, A ;

Hurtado, T ;

Leira, T ;

Obón, M ;

Pascual, C ;

Moro, MA ;

Lizasoain, I ;

Castillo, J ;

Dávalos, A .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2003, 23 (08) :978-984

[4] Rapid cerebral ischemic preconditioning in mice deficient in endothelial and neuronal nitric oxide synthases [J].

Atochin, DN ;

Clark, J ;

Demchenko, IT ;

Moskowitz, MA ;

Huang, PL .

STROKE, 2003, 34 (05) :1299-1303

[5] Neutrophils do not contribute to infarction, oxidative stress, and NO synthase activity in severe brain ischemia [J].

Beray-Berthat, V ;

Palmier, B ;

Plotkine, M ;

Margaill, I .

EXPERIMENTAL NEUROLOGY, 2003, 182 (02) :446-454

[6]

BROWN CM, 2005, NEUR 2005 M WASH DC

[7] Reactive oxygen radicals in signaling and damage in the ischemic brain [J].

Chan, PH .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2001, 21 (01) :2-14

[8] Obligatory role of inducible nitric oxide synthase in ischemic preconditioning [J].

Cho, S ;

Park, EM ;

Zhou, P ;

Frys, K ;

Ross, ME ;

Iadecola, C .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2005, 25 (04) :493-501

[9] Role of inducible nitric oxide synthase in leukocyte extravasation in vivo [J].

Cockrell, A ;

Laroux, FS ;

Jourd'heuil, D ;

Kawachi, S ;

Gray, L ;

Van der Heyde, H ;

Grisham, MB .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 257 (03) :684-686

[10] Inflammation is detrimental for neurogenesis in adult brain [J].

Ekdahl, CT ;

Claasen, JH ;

Bonde, S ;

Kokaia, Z ;

Lindvall, O .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (23) :13632-13637

← 1 2 3 4 5 →