Sirt1 protects the heart from aging and stress

被引：97

作者：

Hsu, Chiao-Po ^{[1
]}

Odewale, Ibrahim ^{[1
]}

Alcendor, Ralph R. ^{[1
]}

Sadoshima, Junichi ^{[1
]}

机构：

[1] Univ Med & Dent New Jersey, Cardiovasc Res Inst, Dept Cell Biol & Mol Med, Newark, NJ 07103 USA

来源：

BIOLOGICAL CHEMISTRY | 2008年 / 389卷 / 03期

关键词：

apoptosis; hormesis; longevity factor; oxidative stress; sirtuin; stress resistance;

D O I：

10.1515/BC.2008.032

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The prevalence of heart diseases, such as coronary artery disease and congestive heart failure, increases with age. Optimal therapeutic interventions that antagonize aging may reduce the occurrence and mortality of adult heart diseases. We discuss here how molecular mechanisms mediating life span extension affect aging of the heart and its resistance to pathological insults. In particular, we review our recent findings obtained from transgenic mice with cardiac-specific overexpression of Sirt1, which demonstrated delayed aging and protection against oxidative stress in the heart. We propose that activation of known longevity mechanisms in the heart may represent a novel cardioprotection strategy against aging and certain types of cardiac stress, such as oxidative stress.

引用

收藏

页码：221 / 231

页数：11

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