Confidence bands for low-dose risk estimation with quantal response data

被引：37

作者：

Al-Saidy, OM ^{[1
]}

Piegorsch, WW

West, RW

Nitcheva, DK

机构：

[1] Sultan Qaboos Univ, Dept Math & Stat, Muscat, Oman

[2] Univ S Carolina, Dept Stat, Columbia, SC 29208 USA

来源：

BIOMETRICS | 2003年 / 59卷 / 04期

关键词：

benchmark analysis; benchmark dose; carcinogenic risk assessment; low-dose extrapolation; multistage model; quantal data; quantitative risk analysis; simultaneous confidence bounds; toxicology;

D O I：

10.1111/j.0006-341X.2003.00121.x

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We study the use of simultaneous confidence bands for low-dose risk estimation with quantal response data, and derive methods for estimating simultaneous upper confidence limits on predicted extra risk under a multistage model. By inverting the upper bands on extra risk, we obtain simultaneous lower bounds on the benchmark dose (BMD). Monte Carlo evaluations explore characteristics of the simultaneous limits under this setting, and a suite of actual data sets are used to compare existing methods for placing lower limits on the BMD.

引用

页码：1056 / 1062

页数：7

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[Anonymous], [No title captured]

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