Zn-mediated rhodium-catalyzed α-trifluoromethylation of ketones via silyl enol ethers

被引：29

作者：

Sato, Kazuyuki ^{[1
]}

Yuki, Takashi ^{[1
]}

Tarui, Atsushi ^{[1
]}

Omote, Masaaki ^{[1
]}

Kumadaki, Itsumaro ^{[1
]}

Ando, Akira ^{[1
]}

机构：

[1] Setsunan Univ, Fac Pharmaceut Sci, Osaka 5730101, Japan

来源：

TETRAHEDRON LETTERS | 2008年 / 49卷 / 22期

关键词：

fluorine; trifluoromethyl; rhodium; silyl enol ether; alpha-position;

D O I：

10.1016/j.tetlet.2008.04.030

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The treatment of silyl enol ethers of ketones with CF3-I and Et2Zn in the presence of RhCl(PPh3)(3) in DME gave alpha-trifluoromethyl ketones in good yields. The reaction can be widely applicable to silyl enol ethers derived from aliphatic or aromatic ketones. In the absence of the rhodium catalyst, the reaction was very slow and the yields were quite poor. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：3558 / 3561

页数：4

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