Molecular mechanisms of AhR functions in the regulation of cytochrome P450 genes

被引：231

作者：

Fujii-Kuriyama, Y

Mimura, J

机构：

[1] Univ Tsukuba, Ctr Tsukuba Adv Res Alliance, Tsukuba, Ibaraki 3058577, Japan

[2] Univ Tsukuba, Inst Basic Med Sci, Tsukuba, Ibaraki 3058577, Japan

[3] Japan Sci & Technol Corp, Solut Oriented Res Sci & Technol, Kawaguchi 3320012, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2005年 / 338卷 / 01期

关键词：

aryl hydrocarbon receptors; cytochrome P450; transcription factor; coactivator; gene regulation;

D O I：

10.1016/j.bbrc.2005.08.162

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

AhR, a ligand-activated transcription factor, mediates xenobiotic signaling to enhance the expression of target genes, including drug-metabolizing cytochrome P450s. The recent development of serveral new techniques, including chromatin immunoprecipitation and RNA interference, has expanded and deepened our knowledge of AhR funciton in the xenobiotic signal transduction. In this review, we briefly summarize our current understanding of the activation and inactivation of AhR activities and discuss the future directions of AhR research. (c) 2005 Elsevier Inc. All rights reserved.

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收藏

页码：311 / 317

页数：7

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