Evaluation of IL18 and IL18R1 polymorphisms: genetic susceptibility to knee osteoarthritis

被引：27

作者：

Hulin-Curtis, S. L. ^{[2
]}

Bidwell, J. L. ^{[1
]}

Perry, M. J. ^{[2
]}

机构：

[1] Univ Bristol, Sch Med Sci, Dept Cellular & Mol Med, Bristol BS8 1TD, Avon, England

[2] Univ Bristol, Sch Vet, Dept Anat, Bristol BS8 1TD, Avon, England

来源：

INTERNATIONAL JOURNAL OF IMMUNOGENETICS | 2012年 / 39卷 / 02期

关键词：

SINGLE NUCLEOTIDE POLYMORPHISMS; RHEUMATOID-ARTHRITIS; IL-18; PROMOTER; ASSOCIATION; POPULATION; DISTINCT; ALPHA; CELLS;

D O I：

10.1111/j.1744-313X.2011.01060.x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学];

摘要：

We examined single-nucleotide polymorphisms (SNPs) in IL18 and IL18/R1 genes and knee OA. IL18 rs1946518 wild-type allele was more frequently observed in cases (P = 0.04). Haplotype 1 was more frequently observed in cases (P = 0.04). Genetic variation in the promoter region of IL18, but not IL18R1, may be associated with OA.

引用

页码：106 / 109

页数：4

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