The origin of sympathetic outflow in heart failure: the roles of angiotensin II and nitric oxide

被引：113

作者：

Zucker, IH ^{[1
]}

Schultz, HD ^{[1
]}

Li, YF ^{[1
]}

Wang, Y ^{[1
]}

Wang, W ^{[1
]}

Patel, KP ^{[1
]}

机构：

[1] Univ Nebraska, Coll Med, Dept Physiol & Biophys, Omaha, NE 68198 USA

来源：

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY | 2004年 / 84卷 / 2-3期

基金：

美国国家卫生研究院;

关键词：

chronic heart failure; baroreflex; medulla; renal nerve activity; neurohumoral regulation;

D O I：

10.1016/j.pbiomolbio.2003.11.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The regulation of sympathetic nerve activity in chronic heart failure (CHF) has been an area of renewed investigation. Understanding the central mechanisms that are responsible for sympatho-excitation in this disease state may help in reducing the deleterious effects of chronic sympatho-excitation. This review will summarize our understanding of abnormal reflex control of the circulation in CHF. The roles of the arterial baroreflex, the chemoreflex, the cardiac sympathetic afferent reflex and the cardiopulmonary reflex are discussed. New experimental techniques that allow genetic manipulation of substances such as nitric oxide synthase in discrete areas of the brain aid in clarifying the role of NO in the modulation of sympathetic tone in the CHF state. Lastly, clinical implications of this work are discussed. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：217 / 232

页数：16

共 108 条

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