Bone marrow transplantation and approaches to avoid graft-versus-host disease (GVHD)

被引:49
作者
Blazar, BR
Murphy, WJ
机构
[1] Univ Minnesota, Div Blood & Marrow Transplantat, Ctr Canc, Minneapolis, MN 55455 USA
[2] Univ Nevada, Sch Med, Dept Microbiol & Immunol, Reno, NV 89557 USA
关键词
graft-versus-host disease; bone marrow transplantation; graft versus leukaemia; cytokines; allogeneic;
D O I
10.1098/rstb.2005.1701
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Haematopoietic stem cell transplantation (HSCT) offers promise for the treatment of haematological and immune disorders, solid tumours, and as a tolerance inducing regimen for organ transplantation. Allogeneic HSCTs engraftment requires inummosuppression and the anti-tumour effects are dependent upon the immune effector cells that are contained within or generated from the donor graft. However, significant toxicities currently limit its efficacy. These problems include: (i) graft-versus-host disease (GVHD) in which donor T cells attack the recipient resulting in multi-organ attack and morbidity, (ii) a profound period of immune deficiency following HSCT, and (iii) donor graft rejection. Currently available methods to prevent or treat GVHD with systemic immunosuppression can lead to impaired immune recovery, increased opportunistic infections, and higher relapse rates. This review will provide an overview of GVHD pathophysiology and discuss the roles of various cells, pathways, and factors in the GVHD generation process and in the preservation of graft-versus-tumour effects. Variables that need to be taken into consideration in attempting to extrapolate preclinical results to the clinical paradigm will be highlighted.
引用
收藏
页码:1747 / 1767
页数:21
相关论文
共 234 条
[1]   Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes [J].
Agata, Y ;
Kawasaki, A ;
Nishimura, H ;
Ishida, Y ;
Tsubata, T ;
Yagita, H ;
Honjo, T .
INTERNATIONAL IMMUNOLOGY, 1996, 8 (05) :765-772
[2]   Characterization of human inducible costimulator ligand expression and function [J].
Aicher, A ;
Hayden-Ledbetter, M ;
Brady, WA ;
Pezzutto, A ;
Richter, G ;
Magaletti, D ;
Buckwalter, S ;
Ledbetter, JA ;
Clark, EA .
JOURNAL OF IMMUNOLOGY, 2000, 164 (09) :4689-4696
[3]   Critical contribution of OX40 ligand to T helper cell type 2 differentiation in experimental leishmaniasis [J].
Akiba, H ;
Miyahira, Y ;
Atsuta, M ;
Takeda, K ;
Nohara, C ;
Futagawa, T ;
Matsuda, H ;
Aoki, T ;
Yagita, H ;
Okumura, K .
JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 191 (02) :375-380
[4]   Prevention of lethal acute GVHD with an agorfistic CD28 antibody and rapamycin [J].
Albert, MH ;
Yu, XZ ;
Martin, PJ ;
Anasetti, C .
BLOOD, 2005, 105 (03) :1355-1361
[5]   MOLECULAR AND BIOLOGICAL CHARACTERIZATION OF HUMAN 4-1BB AND ITS LIGAND [J].
ALDERSON, MR ;
SMITH, CA ;
TOUGH, TW ;
DAVISSMITH, T ;
ARMITAGE, RJ ;
FALK, B ;
ROUX, E ;
BAKER, E ;
SUTHERLAND, GR ;
DIN, WS ;
GOODWIN, RG .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1994, 24 (09) :2219-2227
[6]   Synergistic induction of mitochondrial damage and apoptosis in human leukemia cells by flavopiridol and the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) [J].
Almenara, J ;
Rosato, R ;
Grant, S .
LEUKEMIA, 2002, 16 (07) :1331-1343
[7]   Administration of interleukin-7 after allogeneic bone marrow transplantation improves immune reconstitution without aggravating graft-versus-host disease [J].
Alpdogan, O ;
Schmaltz, C ;
Muriglan, SJ ;
Kappel, BJ ;
Perales, MA ;
Rotolo, JA ;
Halm, JA ;
Rich, BE ;
van den Brink, MRM .
BLOOD, 2001, 98 (07) :2256-2265
[8]   Impaired negative selection of T cells in Hodgkin's disease antigen CD30-deficient mice [J].
Amakawa, R ;
Hakem, A ;
Kundig, TM ;
Matsuyama, T ;
Simard, JJL ;
Timms, E ;
Wakeham, A ;
Mittruecker, HW ;
Griesser, H ;
Takimoto, H ;
Schmits, R ;
Shahinian, A ;
Ohashi, PS ;
Penninger, JM ;
Mak, TW .
CELL, 1996, 84 (04) :551-562
[9]   Selective depletion of donor alloreactive T cells without loss of antiviral or antileukernic responses [J].
Amrolia, PJ ;
Muccioli-Casadei, G ;
Yvon, E ;
Huls, H ;
Sili, U ;
Wieder, ED ;
Bollard, C ;
Heslop, HE ;
Molldrem, JJ ;
Rooney, CM ;
Brenner, MK .
BLOOD, 2003, 102 (06) :2292-2299
[10]   Distinct roles for donor- and host-derived antigen-presenting cells and costimulatory molecules in murine chronic graft-versus-host disease: requirements depend on target organ [J].
Anderson, BE ;
McNiff, JM ;
Jain, D ;
Blazar, BR ;
Shlomchik, WD ;
Shlomchik, MJ .
BLOOD, 2005, 105 (05) :2227-2234