Synthesis of radiolabeled biphenylsulfonamide matrix metalloproteinase inhibitors as new potential PET cancer imaging agents

被引：33

作者：

Fei, XS

Zheng, QH ^{[1
]}

Liu, XA

Wang, JQ

Sun, HB

Mock, BH

Stone, KL

Miller, KD

Sledge, GW

Hutchins, GD

机构：

[1] Indiana Univ, Sch Med, Dept Radiol, Indianapolis, IN 46202 USA

[2] Indiana Univ, Sch Med, Dept Anat, Indianapolis, IN 46202 USA

[3] Indiana Univ, Sch Med, Dept Med, Indianapolis, IN 46202 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 13期

关键词：

D O I：

10.1016/S0960-894X(03)00382-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Novel matrix metalloproteinase (MMP) inhibitor radiotracers, (S)-3-methyl-2-(2',3',4'-methoxybiphenyl-4-sulfonyl-amino)-butyric acid [C-11]methyl ester (la-c), (S)-3-methyl-2-(2',3',4'-fluorobiphenyl-4-sulfonylamino)-butyric acid [C-11]methyl ester (1d-f), and (S)-3-methyl-2-(4'-nitrobiphenyl-4-sulfonylamino)-butyric acid [C-11]methyl ester (1g), a series of substituted biphenylsulfonamide derivatives, have been synthesized for evaluation as new potential positron emission tomography (PET) cancer imaging agents. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：2217 / 2222

页数：6

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