Bone marrow-derived stem cells initiate pancreatic regeneration

被引:471
作者
Hess, D
Li, L
Martin, M
Sakano, S
Hill, D
Strutt, B
Thyssen, S
Gray, DA
Bhatia, M
机构
[1] John P Robarts Res Inst, London, ON N6A 5K8, Canada
[2] Univ Western Ontario, London, ON N6A 4B8, Canada
[3] Asahi Kasei Corp, Cent R&D & Cent Res Lab, Shizuoka 4168501, Japan
[4] Lawson Hlth Res Inst, London, ON N6A 4V2, Canada
[5] Ctr Canc Therapeut, Ottawa, ON K1H 1C4, Canada
关键词
D O I
10.1038/nbt841
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
We show that transplantation of adult bone marrow-derived cells expressing c-kit reduces hyperglycemia in mice with streptozotocin- induced pancreatic damage. Although quantitative analysis of the pancreas revealed a low frequency of donor insulin-positive cells, these cells were not present at the onset of blood glucose reduction. Instead, the majority of transplanted cells were localized to ductal and islet structures, and their presence was accompanied by a proliferation of recipient pancreatic cells that resulted in insulin production. The capacity of transplanted bone marrow-derived stem cells to initiate endogenous pancreatic tissue regeneration represents a previously unrecognized means by which these cells can contribute to the restoration of organ function.
引用
收藏
页码:763 / 770
页数:8
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