Oxidation chemistry and biochemistry of indole and effect of its oxidation product in albino mice

被引：39

作者：

Goyal, RN ^{[1
]}

Kumar, N ^{[1
]}

Singhal, NK ^{[1
]}

机构：

[1] Univ Roorkee, Dept Chem, Roorkee 247667, Uttar Pradesh, India

来源：

BIOELECTROCHEMISTRY AND BIOENERGETICS | 1998年 / 45卷 / 01期

关键词：

indole; electrooxidation; toxicity;

D O I：

10.1016/S0302-4598(98)00066-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Electrochemical oxidation of Indole has been studied in phosphate buffers in the pH range 2.0-10.6 at pyrolytic graphite electrode. Below pH 6.0, the oxidation of Indole occurred in a single le step. The nature of the electrode reaction was found as EC in which charge transfer is followed by irreversible chemical step. A UV absorbing intermediate was noticed at around 235 nm which decayed in a pseudo first order reaction to give trimer as the major product. The trimer was characterized by m.p., H-1 NMR and mass spectrum and a tentative mechanism for its formation is also suggested. A comparison of toxicity of Indole and the oxidation product in albino mice was made by analyzing blood parameters after intracranial injection. The studies clearly suggested that the trimer is more toxic in comparison to Indole. (C) 1998 Elsevier Science S.A.

引用

页码：47 / 53

页数：7

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