Discovery and preclinical pharmacology of a novel, potent, nonsteroidal estrogen receptor agonist/antagonist, CP-336156, a diaryltetrahydronaphthalene

被引：123

作者：

Rosati, RL ^{[1
]}

Jardine, PD

Cameron, KO

Thompson, DD

Ke, HZ

Toler, SM

Brown, TA

Pan, LC

Ebbinghaus, CF

Reinhold, AR

Elliott, NC

Newhouse, BN

Tjoa, CM

Sweetnam, PM

Cole, MJ

Arriola, MW

Gauthier, JW

Crawford, DT

Nickerson, DF

Pirie, CM

Qi, H

Simmons, HA

Tkalcevic, GT

机构：

[1] Pfizer Inc, Div Cent Res, Med Chem, Groton, CT 06340 USA

[2] Pfizer Inc, Div Cent Res, Metab Dis, Groton, CT 06340 USA

[3] Pfizer Inc, Div Cent Res, Drug Metab, Groton, CT 06340 USA

[4] Pfizer Inc, Div Cent Res, Mol Sci, Groton, CT 06340 USA

[5] Pfizer Inc, Div Cent Res, New Leads, Groton, CT 06340 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1998年 / 41卷 / 16期

关键词：

D O I：

10.1021/jm980048b

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：2928 / 2931

页数：4

共 34 条

[1] NASAL ABSORPTION OF 17-ALPHA-ETHINYLOESTRADIOL IN THE RAT [J].

BAWARSHINASSAR, RN ;

HUSSAIN, A ;

CROOKS, PA .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1989, 41 (03) :214-215

[2] 1,2-DIARYL-3,4-DIHYDRONAPHTHALENES - PHOTOFLUOROGENIC LIGANDS FOR THE ESTROGEN-RECEPTOR [J].

BINDAL, RD ;

KATZENELLENBOGEN, JA .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1985, 23 (6A) :929-937

[3] RALOXIFENE (LY139481 HCL) PREVENTS BONE LOSS AND REDUCES SERUM-CHOLESTEROL WITHOUT CAUSING UTERINE HYPERTROPHY IN OVARIECTOMIZED RATS [J].

BLACK, LJ ;

SATO, M ;

ROWLEY, ER ;

MAGEE, DE ;

BEKELE, A ;

WILLIAMS, DC ;

CULLINAN, GJ ;

BENDELE, R ;

KAUFFMAN, RF ;

BENSCH, WR ;

FROLIK, CA ;

TERMINE, JD ;

BRYANT, HU .

JOURNAL OF CLINICAL INVESTIGATION, 1994, 93 (01) :63-69

[4]

BLACK LJ, 1994, Patent No. 605193

[5] FUNCTIONAL-HETEROGENEITY OF UDP-GLUCURONYLTRANSFERASE IN RAT-TISSUES [J].

BOCK, KW ;

CLAUSBRUCH, UCV ;

KAUFMANN, R ;

LILIENBLUM, W ;

OESCH, F ;

PFEIL, H ;

PLATT, KL .

BIOCHEMICAL PHARMACOLOGY, 1980, 29 (04) :495-500

[6]

BOLGER JW, 1974, Patent No. 3822287

[7] Molecular basis of agonism and antagonism in the oestrogen receptor [J].

Brzozowski, AM ;

Pike, ACW ;

Dauter, Z ;

Hubbard, RE ;

Bonn, T ;

Engstrom, O ;

Ohman, L ;

Greene, GL ;

Gustafsson, JA ;

Carlquist, M .

NATURE, 1997, 389 (6652) :753-758

[8]

CAMERON KO, 1995, Patent No. 10513

[9]

CASTANER J, 1978, Drugs of the Future, V3, P211

[10] SEX-RELATED DIFFERENCES IN REGULATION OF CYTOPLASMIC ESTROGEN-RECEPTOR LEVELS IN RESPONSIVE TISSUES OF RAT [J].

CIDLOWSKI, JA ;

MULDOON, TG .

ENDOCRINOLOGY, 1976, 98 (04) :833-841

← 1 2 3 4 →