Total synthesis of 3-hydroxy-6-oxaestra-1,3,5(10)-trien-17-one

被引：5

作者：

Cao, ZS ^{[1
]}

Liehr, JG ^{[1
]}

机构：

[1] UNIV TEXAS,MED BRANCH,DEPT PHARMACOL & TOXICOL,GALVESTON,TX 77555

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1996年 / 08期

关键词：

D O I：

10.1039/p19960000841

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The modified steroid estrogen, 3-hydroxy-6-oxaestra-1,3,5(10)-trien-17-one, i.e. 6-oxaestrone 8 has been prepared from 7-methoxychromanone 1 by de novo synthesis of the modified steroid ring system. The H-1 and C-13 NMR data for the intermediate products 3, 4, 4a, 4b, 4c, 6, 7, and for the final product 8 support the proposed structures, A mechanism for the ring-closure reaction of 3 to intermediate products 4 and 4a is proposed.

引用

页码：841 / 844

页数：4

共 8 条

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