Matrix metalloproteinases in remodeling of the normal and neoplastic mammary gland

被引：52

作者：

Rudolph-Owen, LA ^{[1
]}

Matrisian, LM ^{[1
]}

机构：

[1] Vanderbilt Univ, Ctr Med, Dept Cell Biol, Nashville, TN 37232 USA

来源：

JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA | 1998年 / 3卷 / 02期

关键词：

MMP; matrilysin; stromelysin; gelatinase; collagenase; breast cancer; mammary development;

D O I：

10.1023/A:1018746923474

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Alterations in mammary gland structure and function are associated with changes in the expression of members of the matrix metalloproteinase (MMP)(3) family of enzymes. In this review, the evidence for a role for specific MMPs in mammary gland development and cellular differentiation, proliferation, and apoptosis is discussed. In addition, MMP expression is altered during the development and progression of preneoplastic and neoplastic breast lesions. The expression of MMP family members in human breast cancer is described, and studies with mouse model systems addressing the role of MMPS in the initiation, growth, invasion, and metastasis of breast neoplasms are reviewed.

引用

页码：177 / 189

页数：13

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