Effect of N-cadherin misexpression by the mammary epithelium in mice

被引：19

作者：

Knudsen, KA

Sauer, C

Johnson, KR

Wheelock, MJ

机构：

[1] Lankenau Inst Med Res, Wynnewood, PA 19096 USA

[2] Univ Nebraska, Med Ctr, Coll Dent, Dept Oral Biol, Omaha, NE 68198 USA

[3] Univ Nebraska, Med Ctr, Coll Med, Dept Biochem & Mol Biol, Omaha, NE 68198 USA

[4] Univ Nebraska, Med Ctr, Coll Med, Dept Genet Cell Biol & Anat, Omaha, NE 68198 USA

[5] Univ Nebraska, Med Ctr, Coll Med, Dept Pathol & Microbiol, Omaha, NE 68198 USA

[6] Univ Nebraska, Med Ctr, Eppley Inst Res Canc & Allied Dis, Omaha, NE 68198 USA

[7] Univ Nebraska, Med Ctr, Eppley Canc Ctr, Omaha, NE 68198 USA

来源：

JOURNAL OF CELLULAR BIOCHEMISTRY | 2005年 / 95卷 / 06期

关键词：

N-cadherin; mammary gland; tumorigenesis;

D O I：

10.1002/jcb.20469

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

N-cadherin is not typically expressed by epithelial cells. However, it is detected in breast cancers and increases tumor cell migration and invasion in vitro. To explore its misexpression, we generated transgenic mice with N-cadherin in the mammary epithelium. Mammary glands appeared normal and no tumors arose spontaneously. To investigate N-cadherin misexpression in mammary tumors, neu was overexpressed through breeding. Tumors developed in +/neu and N-cadherin/neu mice, although few tumors in bitransgenic mice expressed N-cadherin, and they did not differ from N-cadherin-negative tumors.

引用

页码：1093 / 1107

页数：15

共 38 条

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