Stereoselective synthesis and biological activity of cis azetidinones as cholesterol absorption inhibitors

被引：29

作者：

McKittrick, BA ^{[1
]}

Ma, K ^{[1
]}

Dugar, S ^{[1
]}

Clader, JW ^{[1
]}

Davis, H ^{[1
]}

Czarniecki, M ^{[1
]}

McPhail, AT ^{[1
]}

机构：

[1] DUKE UNIV,DEPT CHEM,DURHAM,NC 27708

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 16期

关键词：

D O I：

10.1016/0960-894X(96)00347-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The C-3 sidechain of azetidinones related to SCH 48461 was modified by introducing a hydroxyl group at the 1' position. This led to the discovery of the cis azetidinone 2c, which had improved CAI activity. Compound 2c was prepared using a selective reduction and silane mediated debromination to control the relative stereochemistry of the three centers. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：1947 / 1950

页数：4

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